MyBioSource.com's anti-human Receptor tyrosine-protein kinase ErbB-1 monoclonal antibody is a Mouse monoclonal antibody. The anti-human Receptor tyrosine-protein kinase ErbB-1 monoclonal antibody was generated using EGFR, egfra, epidermal growth factor receptor, ERBB, ERBB1, Errp, and HER1 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: ELISA, and Flow Cytometry.
Description
Background: Epidermal growth factor receptor (EGFR; ErbB-1) is a 170-kDa transmembrane glycoprotein encoded by the HER1 proto-oncogene. It belongs to the EGFR family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her3 (ErbB-3) and Her4 (ErbB-4). ErbB-1 is expressed on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor ? (TGF?). Growth factor binding to the extracellular domain of ErbB-1 induces formation of homoand heterodimers with another member of the ErbB receptor family. The EGFR signaling pathway is one of the most important pathways that regulate growth, survival, proliferation and differentiation in mammalian cells, while over-expression of ErbB-1 have been associated with a number of cancers, including lung cancer and glioblastoma (2,3)